Fischer’s lock and key model
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Enzyme substrate union depends upon the
reciprocal fit
between the structure of enzyme and the structure of the
substrate.
between the structure of enzyme and the structure of the
substrate.
-
The substrate and active site of enzyme fit each
other more or
less like a lock and key.
less like a lock and key.
-
The enzyme substrate union results in the
release of energy.
-
The energy released helps the substrate molecule
to attain
activation energy.
activation energy.
-
In the activated state certain bonds of the
enzyme-substrate
complex become susceptible to cleavage.
complex become susceptible to cleavage.
-
This cleavage produces product and the enzyme
remains
unchanged.
unchanged.
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